SidaGhanaV1, Main, Exploration, bibRecord, 000679

Association between high aflatoxin B1 levels and high viral load in HIV-positive people

Identifieur interne : 000679 ( Main/Exploration ); précédent : 000678; suivant : 000680

Association between high aflatoxin B1 levels and high viral load in HIV-positive people

Auteurs : P. E. Jolly [États-Unis] ; S. Inusah [États-Unis] ; B. Lu [États-Unis] ; W. O. Ellis [Ghana] ; A. Nyarko [Ghana] ; T. D. Phillips [États-Unis] ; J. H. Williams [États-Unis]

Source :

World mycotoxin journal : (Print) [ 1875-0710 ] ; 2013.

RBID : Pascal:13-0349936

Descripteurs français

Pascal (Inist)
- Association, Aflatoxine B1, Albumine, Ghana, Virus immunodéficience humaine, Mycotoxine.
Wicri :
- geographic : Ghana.
- topic : Association.

English descriptors

KwdEn :
- Aflatoxin B1, Albumin, Association, Ghana, Human immunodeficiency virus, Mycotoxin.

Abstract

Since both aflatoxin and the human immunodeficiency virus (HIV) cause immune suppression, chronic exposure to aflatoxin in HIV-positive people could lead to higher levels of virus replication. This study was conducted to examine the association between aflatoxin B₁ albumin adduct (AF-ALB) levels and HIV viral load. Antiretroviral naive HIV-positive people (314) with median CD4 count of 574 cells/μl blood (mean ± standard deviation = 630±277) were recruited in Kumasi, Ghana. Sociodemographic and health data, and blood samples were collected from participants. The plasma samples were tested for AF-ALB and HIV viral load. Univariate logistic regression analysis was conducted using viral load (high/low) as the outcome and AF-ALB quartiles as exposure. Multivariable logistic regression analysis was performed between quartile AF-ALB, viral load and CD4 adjusting for sex, age, and year of HIV diagnosis. Both univariate and multivariable logistic regression showed that viral load increased as AF-ALB levels increased. By univariate analysis, high viral load was 2.3 times more likely among persons in the third AF-ALB quartile (95% confidence interval (CI): 1.13, 4.51), and 2.9 times more likely among persons in the fourth AF-ALB quartile (CI: 1.41, 5.88), compared to persons in the first quartile. In the multivariable model, persons in the fourth AF-ALB quartile were about 2.6 times more likely to have high viral loads than persons in the first quartile (CI: 1.19-5.69). When AF-ALB and viral load were log transformed and linear regression analysis conducted, the univariate linear regression analysis showed that for each pg/mg increase in AF-ALB, viral load increased by approximately 1.6 copies/ml (P=0.0006). The association was marginally significant in the adjusted linear regression model (i.e. for each pg/mg increase in AF-ALB, the mean viral load increased by approximately 1.3 copies/ml, P=0.073). These data show strong and consistent increases in HIV viral load with increasing AF-ALB levels. Since the median and mean CD4 were greater than 500 cells for participants in each AF-ALB quartile, the results indicate that the immune modulating and virus transcription effects of aflatoxin may occur quite early in HIV infection, even while the CD4 count is still above 500, resulting in higher viral loads.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000007
to stream PascalFrancis, to step Curation: 000123
to stream PascalFrancis, to step Checkpoint: 000010
to stream Main, to step Merge: 000680
to stream Main, to step Curation: 000679

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Association between high aflatoxin B<sub>1</sub>
 levels and high viral load in HIV-positive people</title>
<author><name sortKey="Jolly, P E" sort="Jolly, P E" uniqKey="Jolly P" first="P. E." last="Jolly">P. E. Jolly</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>University of Alabama at Birmingham, Department of Epidemiology, School of Public Health, 1665 University Boulevard, RPHB 217</s1>
<s2>Birmingham, AL 35294-0022</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Inusah, S" sort="Inusah, S" uniqKey="Inusah S" first="S." last="Inusah">S. Inusah</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>University of Alabama at Birmingham, Department of Epidemiology, School of Public Health, 1665 University Boulevard, RPHB 217</s1>
<s2>Birmingham, AL 35294-0022</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lu, B" sort="Lu, B" uniqKey="Lu B" first="B." last="Lu">B. Lu</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>University of Alabama at Birmingham, Department of Epidemiology, School of Public Health, 1665 University Boulevard, RPHB 217</s1>
<s2>Birmingham, AL 35294-0022</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ellis, W O" sort="Ellis, W O" uniqKey="Ellis W" first="W. O." last="Ellis">W. O. Ellis</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Kwame Nkrumah University of Science and Technology</s1>
<s2>Kumasi</s2>
<s3>GHA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Ghana</country>
<wicri:noRegion>Kwame Nkrumah University of Science and Technology</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nyarko, A" sort="Nyarko, A" uniqKey="Nyarko A" first="A." last="Nyarko">A. Nyarko</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Kumasi South Regional Hospital</s1>
<s2>Kumasi</s2>
<s3>GHA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Ghana</country>
<wicri:noRegion>Kumasi South Regional Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Phillips, T D" sort="Phillips, T D" uniqKey="Phillips T" first="T. D." last="Phillips">T. D. Phillips</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Veterinary Integrative Biosciences, Texas A&M University, Mail Stop 4458</s1>
<s2>College Station, TX 77843</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Williams, J H" sort="Williams, J H" uniqKey="Williams J" first="J. H." last="Williams">J. H. Williams</name>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>College of Agricultural and Environmental Sciences, University of Georgia, 1109 Experiment St</s1>
<s2>Griffin, GA 30223</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">13-0349936</idno>
<date when="2013">2013</date>
<idno type="stanalyst">PASCAL 13-0349936 INIST</idno>
<idno type="RBID">Pascal:13-0349936</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000007</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000123</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000010</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000010</idno>
<idno type="wicri:doubleKey">1875-0710:2013:Jolly P:association:between:high</idno>
<idno type="wicri:Area/Main/Merge">000680</idno>
<idno type="wicri:Area/Main/Curation">000679</idno>
<idno type="wicri:Area/Main/Exploration">000679</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Association between high aflatoxin B<sub>1</sub>
 levels and high viral load in HIV-positive people</title>
<author><name sortKey="Jolly, P E" sort="Jolly, P E" uniqKey="Jolly P" first="P. E." last="Jolly">P. E. Jolly</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>University of Alabama at Birmingham, Department of Epidemiology, School of Public Health, 1665 University Boulevard, RPHB 217</s1>
<s2>Birmingham, AL 35294-0022</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Inusah, S" sort="Inusah, S" uniqKey="Inusah S" first="S." last="Inusah">S. Inusah</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>University of Alabama at Birmingham, Department of Epidemiology, School of Public Health, 1665 University Boulevard, RPHB 217</s1>
<s2>Birmingham, AL 35294-0022</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lu, B" sort="Lu, B" uniqKey="Lu B" first="B." last="Lu">B. Lu</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>University of Alabama at Birmingham, Department of Epidemiology, School of Public Health, 1665 University Boulevard, RPHB 217</s1>
<s2>Birmingham, AL 35294-0022</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ellis, W O" sort="Ellis, W O" uniqKey="Ellis W" first="W. O." last="Ellis">W. O. Ellis</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Kwame Nkrumah University of Science and Technology</s1>
<s2>Kumasi</s2>
<s3>GHA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Ghana</country>
<wicri:noRegion>Kwame Nkrumah University of Science and Technology</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nyarko, A" sort="Nyarko, A" uniqKey="Nyarko A" first="A." last="Nyarko">A. Nyarko</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Kumasi South Regional Hospital</s1>
<s2>Kumasi</s2>
<s3>GHA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Ghana</country>
<wicri:noRegion>Kumasi South Regional Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Phillips, T D" sort="Phillips, T D" uniqKey="Phillips T" first="T. D." last="Phillips">T. D. Phillips</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Veterinary Integrative Biosciences, Texas A&M University, Mail Stop 4458</s1>
<s2>College Station, TX 77843</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Williams, J H" sort="Williams, J H" uniqKey="Williams J" first="J. H." last="Williams">J. H. Williams</name>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>College of Agricultural and Environmental Sciences, University of Georgia, 1109 Experiment St</s1>
<s2>Griffin, GA 30223</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">World mycotoxin journal : (Print)</title>
<idno type="ISSN">1875-0710</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">World mycotoxin journal : (Print)</title>
<idno type="ISSN">1875-0710</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aflatoxin B1</term>
<term>Albumin</term>
<term>Association</term>
<term>Ghana</term>
<term>Human immunodeficiency virus</term>
<term>Mycotoxin</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Association</term>
<term>Aflatoxine B1</term>
<term>Albumine</term>
<term>Ghana</term>
<term>Virus immunodéficience humaine</term>
<term>Mycotoxine</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Association</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Since both aflatoxin and the human immunodeficiency virus (HIV) cause immune suppression, chronic exposure to aflatoxin in HIV-positive people could lead to higher levels of virus replication. This study was conducted to examine the association between aflatoxin B<sub>1</sub>
 albumin adduct (AF-ALB) levels and HIV viral load. Antiretroviral naive HIV-positive people (314) with median CD4 count of 574 cells/μl blood (mean ± standard deviation = 630±277) were recruited in Kumasi, Ghana. Sociodemographic and health data, and blood samples were collected from participants. The plasma samples were tested for AF-ALB and HIV viral load. Univariate logistic regression analysis was conducted using viral load (high/low) as the outcome and AF-ALB quartiles as exposure. Multivariable logistic regression analysis was performed between quartile AF-ALB, viral load and CD4 adjusting for sex, age, and year of HIV diagnosis. Both univariate and multivariable logistic regression showed that viral load increased as AF-ALB levels increased. By univariate analysis, high viral load was 2.3 times more likely among persons in the third AF-ALB quartile (95% confidence interval (CI): 1.13, 4.51), and 2.9 times more likely among persons in the fourth AF-ALB quartile (CI: 1.41, 5.88), compared to persons in the first quartile. In the multivariable model, persons in the fourth AF-ALB quartile were about 2.6 times more likely to have high viral loads than persons in the first quartile (CI: 1.19-5.69). When AF-ALB and viral load were log transformed and linear regression analysis conducted, the univariate linear regression analysis showed that for each pg/mg increase in AF-ALB, viral load increased by approximately 1.6 copies/ml (P=0.0006). The association was marginally significant in the adjusted linear regression model (i.e. for each pg/mg increase in AF-ALB, the mean viral load increased by approximately 1.3 copies/ml, P=0.073). These data show strong and consistent increases in HIV viral load with increasing AF-ALB levels. Since the median and mean CD4 were greater than 500 cells for participants in each AF-ALB quartile, the results indicate that the immune modulating and virus transcription effects of aflatoxin may occur quite early in HIV infection, even while the CD4 count is still above 500, resulting in higher viral loads.</div>
</front>
</TEI>
<affiliations><list><country><li>Ghana</li>
<li>États-Unis</li>
</country>
<region><li>Alabama</li>
<li>Géorgie (États-Unis)</li>
<li>Texas</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Alabama"><name sortKey="Jolly, P E" sort="Jolly, P E" uniqKey="Jolly P" first="P. E." last="Jolly">P. E. Jolly</name>
</region>
<name sortKey="Inusah, S" sort="Inusah, S" uniqKey="Inusah S" first="S." last="Inusah">S. Inusah</name>
<name sortKey="Lu, B" sort="Lu, B" uniqKey="Lu B" first="B." last="Lu">B. Lu</name>
<name sortKey="Phillips, T D" sort="Phillips, T D" uniqKey="Phillips T" first="T. D." last="Phillips">T. D. Phillips</name>
<name sortKey="Williams, J H" sort="Williams, J H" uniqKey="Williams J" first="J. H." last="Williams">J. H. Williams</name>
</country>
<country name="Ghana"><noRegion><name sortKey="Ellis, W O" sort="Ellis, W O" uniqKey="Ellis W" first="W. O." last="Ellis">W. O. Ellis</name>
</noRegion>
<name sortKey="Nyarko, A" sort="Nyarko, A" uniqKey="Nyarko A" first="A." last="Nyarko">A. Nyarko</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaGhanaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000679 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000679 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    SidaGhanaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:13-0349936
   |texte=   Association between high aflatoxin B1 levels and high viral load in HIV-positive people
}}

This area was generated with Dilib version V0.6.31.
Data generation: Tue Nov 7 18:07:38 2017. Site generation: Tue Mar 5 15:01:57 2024

	Le SIDA au Ghana (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Le SIDA au Ghana (serveur d'exploration)

Association between high aflatoxin B1 levels and high viral load in HIV-positive people

Association between high aflatoxin B1 levels and high viral load in HIV-positive people

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri